Decellularized Tooth Bud Scaffolds for Tooth Regeneration

Characterization of natural, decellularized and reseeded porcine tooth bud matrices.

Dental tissue engineering efforts have yet to identify scaffolds that instruct the formation of bioengineered teeth of predetermined size and shape. Here we investigated whether extracellular matrix (ECM) molecules present in natural tooth scaffolds can provide insight on how to achieve this goal. We describe methods to effectively decellularize and demineralize porcine molar tooth buds, while ...

Does wisdom tooth provide tooth germs for tooth regeneration?

Introduction Regenerating a tooth completely in human oral cavity is not achieved by current studies yet. Here, we have conceived a man-induced method to construct a teeth germ which might be used to regenerate a tooth in vivo. This idea was generated by traits of the development of the compound odontoma, a benign tumour of tooth malformation. This is a kind of developmental tooth malformation,...

Whole Tooth Regeneration Using a Bioengineered Tooth

Tooth Regeneration with Stem Cell Sources

Introduction: During the last decade, advances in tissue engineering and stem cell-based tooth regeneration have provided realistic and attractive means of replacing lost or damaged teeth. The first adult stem cells isolated from dental tissues were dental pulp stem cells (DPSCs). When transplanted with hydroxyl apatite/tri calcium phosphate (HA/TCP) powder, they formed a dentin-like structure...

Bone and Tooth Regeneration in Maxillofacial Region

1Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan 2USAA Foundation, College of Engineering, The University of Texas at San Antonio, San Antonio, TX 78249, USA 3Department of Oral and Maxillofacial Surgery, Center of Operative Medicine II, Heinrich Heine University, 40225 Düsseldorf, Germany 4Forensic Odontology, Melbourne Dental ...